With regular screening, blood tests and effective diabetes management, the incidence of complications can be greatly reduced or prevented. Short term complications such us high blood glucose levels (hyperglycaemia) or low blood glucose levels (hypoglycaemia) are part of daily life with diabetes, and the risk of severe hypoglycemia and diabetes keto-acidosis (DKA), in particular in those with Type 1 diabetes, is always a side effect of insulin treatment (or the lack of it), and may occur rapidly.

 

Long-term complications such as retinopathy or neuropathy develop slowly and are a consequence of a long stretch of high glucose levels in your body. See below more information about diabetes long-term complications.

Long-Term Complications

Diabetes long-term complications can be broken down into two categories;

  • Microvascular (small blood vessels)
  • Macrovascular (large blood vessels)

International Diabetes Federation Europe prepared an illustration summarising the most common complications and comorbidities in people with diabetes.

Long-term complications can be prevented with accurate and effective diabetes management, good access to care, medicines and treatment the key is to keep glucose in recommended levels for the majority of time.

EYES

Diabetic Retinopathy is a serious eye complication of diabetes caused by damage to the small blood vessels of the retina, the light-sensitive tissue at the back of the eye.

 

If your blood glucose levels are consistently high, it can lead to this damage which can lead to vision loss and even blindness if not detected and treated early. When the blood vessels are damaged, they can swell and leak. High blood pressure and cholesterol can also increase your risk of eye problems.

 

Symptoms

  • Blurred or fluctuating vision
  • Dark spots or floaters
  • Impaired colour vision
  • Sudden vision loss
  • Difficulty seeing at night

 

Prevention & Monitoring

To prevent complications in your eyes, you should:

  • Have your eyes checked by DiabeticRetina Screening programme.
  • Tight glucose levels. Aim for HbA1c between 48-53 mmol/mol (6.5-7%)
  • Monitor blood pressure and cholesterol
  • Don’t smoke
  • Exercise or move regularly

Early stages often have no symptoms, which is why DiabeticRetina Screening is critical.

For more information visit www.diabeticretinascreen.ie, contact 1800 454555, or email info@diabeticretinascreen.ie.

KIDNEYS

Diabetic Nephropathy (also called diabetic kidney disease) is a progressive kidney condition caused by long-term high blood glucose levels. It is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide.

 

What Happens in Diabetic Nephropathy?

High blood sugar levels damage the tiny filtering units in the kidneys (called glomeruli), leading to:

  • Leaky kidneys: proteins like albumin leak into the urine
  • Decreased filtering ability: leading to buildup of waste in the blood
  • Eventually kidney failure, requiring dialysis or transplant

 

Progressive Symptoms may include:

  • Swelling in legs, ankles, feet (oedema)
  • Fatigue and weakness
  • Foamy or bubbly urine (due to protein)
  • Nausea, vomiting
  • Loss of appetite
  • High blood pressure
  • Itchy skin
  • Confusion or trouble concentrating (late stage)

 

Signs and Symptoms

Early Stage – Often silent (no symptoms), but urine tests may show:

  • Microalbuminuria (small amounts of protein in urine)

A kidney health check is a quick and straightforward way to assess how well your kidneys are functioning. It can often be done at your GP or healthcare professional as part of a routine medical appointment.

NERVES

Diabetic Neuropathy is a type of nerve damage caused by prolonged high blood sugar levels in people with diabetes. It affects up to 50% of people living with diabetes and can involve nerves in various parts of the body  especially the legs and feet.

It can affect different types of nerves in your body, including in your feet, organs and muscles. Nerves carry messages between the brain and every part of our bodies so that we can see, hear, feel and move. They also carry signals to parts of the body such as the heart, making it beat at different speeds, and the lungs, so we can breathe.

Over time, high blood glucose levels can damage the small blood vessels that supply the nerves in your body. This stops essential nutrients reaching the nerves, which means the nerve fibres can become damaged, and they may disappear. This can cause problems in many different parts of your body, depending on the type of nerve affected.

Types of Diabetic Neuropathy

Peripheral Neuropathy (most common)

  • Affects feet, legs, hands, and arms.
    • Numbness or reduced ability to feel pain or temperature
    • Tingling or burning sensations
    • Sharp pains or cramps
    • Muscle weakness
    • Loss of balance and coordination
    • Foot ulcers, infections, or deformities (due to unnoticed injuries)

What can You do?

Get your feet checked

See your GP or podiatrist at least once a year for a thorough foot exam. You may consider seeing our Diabetes Ireland podiatrist and get your feet checked in one of our clinics in Dublin and Cork. For more information click here.

  • Know your feet well. Wash, dry, and check your feet every day. Check for redness, swelling, cuts, pus discharge, splinters or blisters. Take care to look between your toes, around heels and nail edges, and at the soles of your feet. If you have difficulty with your vision, get someone to check for you.
  • Cut your toenails straight across. Don’t cut into corners. Gently file any sharp edges. Ask for help if you can’t see well or reach your feet.
  • Moisturise. Do this daily to avoid dry skin.
  • Never use over-the-counter corn cures. Ask your GP for advice instead.
  • Cover your feet. Use clean socks or stockings without rough seams.
  • No tight socks or stockings.
  • Protect your feet. Wear shoes that fit well. Make sure it’s the right length (a thumb width longer than your longest toe), width and depth, and have been checked for stones, pins, bunions or anything else which could cause injury.
  • Stay cool. Keep your feet away from direct heat such as heaters, hot water bottles, and electric blankets.
  • Get medical advice early. If you notice any changes or problems, see your GP.

Diabetes Ireland Care Centres, located in Dublin and Cork offer services including podiatry (footcare) and retinal eye screening for individuals living with diabetes.

 

Autonomic Neuropathy

  • Affects involuntary body functions (heart, stomach, bladder, sexual organs etc.)

Symptoms:

  • Gastroparesis (nausea, vomiting, bloating)
  • Bladder problems (incontinence or retention)
  • Sexual dysfunction (e.g., erectile dysfunction (ED))
  • Abnormal sweating
  • Drop in blood pressure when standing (orthostatic hypotension)
  • Difficulty sensing low blood sugar (hypoglycaemia unawareness)

Prevention Tips

  • Tight glucose levels (aim at HbA1c 48-53mmol/mol)
  • Maintain healthy weight
  • Do not smoke
  • Monitor and manage blood pressure/cholesterol
  • Exercise and move regularly

Macrovascular Complications (damage to large blood vessels):

  • Cardiovascular disease (CVD) is the leading cause of death in people with diabetes. Diabetes significantly increases the risk of heart attacks, strokes, and other heart-related conditions — often developing earlier and with more severity compared to those without.
  • Adults with diabetes are 2 to 4 times more likely to die of heart disease or stroke.
  • More than 2/3 of people with diabetes have high blood pressure or use antihypertensive medications.

 

How Diabetes Affects the Cardiovascular System

Chronically high blood glucose levels can:

  1. Damage blood vessels (endothelial dysfunction)
  2. Accelerate atherosclerosis (plaque buildup in arteries)
  3. Raise blood pressure and cholesterol levels
  4. Promote inflammation and clot formation

Risk Factors for CVD in People with Diabetes

  • Long diabetes duration
  • Chronically high glucose levels (high HbA1c)
  • High blood pressure (hypertension)
  • Abnormal cholesterol levels (dyslipidaemia)
  • Obesity
  • Smoking
  • Sedentary lifestyle
  • Chronic inflammation

This leads to a higher risk of:

  • Coronary artery disease (CAD) → heart attacks
  • Cerebrovascular disease → strokes
  • Peripheral artery disease (PAD) → leg pain, risk of amputation
  • Heart failure → impaired pumping function of the heart

 

Unfortunately, diabetes often occurs together with high blood pressure and high cholesterol. Therefore, when you have diabetes, it is essential that you monitor and manage both your blood pressure, cholesterol, and blood glucose levels.

Blood pressure and diabetes

  • High blood pressure is often common in people with diabetes and is called Hypertension
  • Blood pressure is the pressure of the blood in the arteries as the heart pumps it around the body. High blood pressure can result in increased risks of stroke, heart disease, kidney disease, eye disease and nerve damage
  • Diabetes changes the body chemistry, thus increases the risk of blood pressure
  • People with diabetes should get their blood pressure checked regularly

When to check your blood pressure

Have your blood pressure checked at every doctor’s visit, at least:

  • Every six months for people with normal blood pressure
  • Three months for people with high blood pressure
  • Every 4-8 weeks if your blood pressure medication is being changed
  • Home blood pressure monitors are available to purchase at some pharmacies. However, it’s best to talk to your doctor first if you are thinking of buying one.

Target Blood Pressure for Diabetes

For most people with diabetes, the target blood pressure is less than 140/90 mmHg. However, some individuals, especially those with kidney disease or had a previous cardiac event, may have a lower target, such as less than 130/80 mmHg, as recommended by their healthcare team.

Prevention

  • Don’t smoke
  • Lose excess weight
  • Do regular physical activity (30 minutes each day on most days of the week)
  • Have less salt by limiting processed and takeaway foods and not adding salt in cooking afterwards
  • Limit alcohol to 2 standard drinks per day for men, 1 standard drink per day for women, with 2 alcohol free days per week
  • While tablets may be necessary to help reduce blood pressure, they are in addition to, and not a substitute for, a healthy eating plan and regular physical activity. It is not unusual to need as many as three or four medications to control blood pressure

High Cholesterol and diabetes

  • Cholesterol is a fat that is transported in the blood in small particles called lipoproteins.
  • If your cholesterol is too high, then the extra fat in your blood sticks to the walls of your blood vessels.
  • This fatty material can build up inside the arteries to your heart. This is known as atherosclerosis. Over time, your arteries may become narrow, stopping enough oxygen rich blood getting to your heart.
  • If some of the fatty material breaks off, it can cause a blood clot. If the clot blocks the main arteries to your heart, called the coronary arteries, it can cut off the supply of blood and oxygen to your heart, causing a heart attack.

 

Your GP or healthcare professional will measure your total cholesterol level as well as the different types of lipoproteins to assess whether you are at risk of artery disease.

Target Cholesterol for diabetes

  • Total or Overall Cholesterol: below 4.5
  • LDL (bad)or Low-Density Lipoprotein – less than or equal to 1.8
  • HDL (good) or High-Density Lipoprotein – above 1.0 for Men, above 1.3 for Women
  • Triglycerides – less than or equal to 1.7

Prevention & Management Strategies

  • Target blood glucose levels and HbA1c (individualised)
  • Medications such as statins
  • Blood Pressure Control (Goal <130/80mmHg)
  • Cholesterol Management (Goal LDL <1.8)
  • Lifestyle modifications, such as healthy diet and regular physical activity
  • Smoking cessation
  • Limit alcohol

HbA1c and diabetes

  • HbA1c is what is known as glycated haemoglobin (A1C). This is something that is made when the glucose in your body sticks to your red blood cells, so the more of it that sticks to your blood cells the more it builds up in your blood.
  • Red blood cells are active for around 2-3 months, which is why the reading should be done quarterly.
  • Your GP or healthcare professional will request an HbA1c measurement for you. This is carried out by a blood test. This result determines how your diabetes is managed and how you can prevent complications.
  • Most people will have a test every 3 to 6 months. But you may need it more often if you’re planning a pregnancy or have had your medications or treatment changed.
  • A HbA1c test is also used to diagnose diabetes or determine if individuals have prediabetes Link to Prediabetes page **
  • Your HbA1c can change for lots of reasons such as illness, taking medications such as steroids, changes in lifestyle or stress.

 

Target HbA1c for diabetes

The target level for diabetes is 48mmol/mol (6.5%).

Prediabetes level is 39mmol/mol-47mmol/mol. (6-6.5%)

Normal level is below 39mmol/mol. (<6%). Targets for older people may be individualised. Speak to your GP or healthcare professional about your HbA1c, know your numbers!

 

Peripheral Arterial Disease (PAD) and Peripheral Vascular Disease (PVD) are common and serious complications of diabetes. They involve narrowing or blockages of the arteries that supply blood to the legs and feet, usually due to atherosclerosis (plaque build up). Diabetes significantly increases the risk and severity of PAD/PVD.

 

How Diabetes Increases Risk of PVD/PAD

  • Raised blood glucose levels can damage blood vessels and accelerate plaque buildup.
  • Diabetes often leads to smaller, more diffuse blockages, especially in the lower legs and feet.
  • Reduced circulation + nerve damage (neuropathy) = high risk of foot ulcers, infections, and amputations.

 

Symptoms of PAD/PVD in Diabetics

Symptoms may be silent in early stages, especially in people living with diabetes with neuropathy, but common signs include:

  • Leg pain when walking (claudication), relieved by rest
  • Numbness or weakness in the legs
  • Cold feet or legs
  • Sores or ulcers on feet/toes that don’t heal
  • Shiny skin, hair loss, or discoloration of legs
  • Weak or absent pulses in the feet

 

The treatment goals for peripheral artery disease (PAD) are:

  • Manage symptoms, such as leg pain, so exercise is comfortable
  • Improve artery health to reduce the risk of heart attack, stroke, and other complications
  • Lifestyle changes
  • Medication
  • Surgery
  • Don’t smoke or use tobacco
  • Get regular exercise
  • Eat a healthy diet

Other Complications

Skin Conditions: Bacterial/fungal infections, diabetes dermopathy.

Diabetes-related dermopathy (often called “shin spots”) is a common skin condition that affects people who are living with diabetes.

Diabetes-related dermopathy looks like small, round pink, reddish or brown patches on your skin.

They can look like scars and be indented. They’re generally 1 centimetre to 2.5 centimetres in size.

The patches are harmless and don’t itch, ooze liquid, or cause pain. Diabetes-related dermopathy most often appears on the front of both your lower legs (on your shins), but one leg may have more patches than the other.

It can also appear on other parts of your body, such as your thighs and arms.

Gum disease also called periodontal gum disease, is the most common and serious mouth problem related to diabetes. Untreated, the disease advances in stages, from inflamed gums to tooth loss. High levels of blood glucose increase the risk that gum disease will progress from mild to severe.

 

See your dentist right away if you notice any signs or symptoms of mouth problems.

  • tell your dentist about your diabetes, including how long you’ve had the disease, any diabetes-related problems you may have, and any medicines you take
  • keep your dentist updated on any changes to your health or medications
  • follow your dentist’s advice on how to prevent and treat mouth problems from diabetes

 

Diabetes & sexual health

A healthy sexual relationship can be an important part of your life. While most people with diabetes can lead a normal sex life, diabetes may contribute to sexual problems for both men and women.

 

Men and diabetes

The most common problem for men is erectile dysfunction. This is where men have difficulty getting aroused long enough for intercourse due to reduced blood flow and nerve damage. There are many causes, such as being tired, stressed, depressed, or drinking too much alcohol. Erectile dysfunction can also be caused by certain medications taken for high blood pressure, depression, or stomach ulcers.

There are many ways to treat erectile dysfunction:

  • Tablets (Viagra)
  • Prostaglandin injection into the side of the penis
  • Devices such as the vacuum pump
  • Surgery, such as penile implants.

Chat with your doctor about all the options to decide what is best for you.

 

Sexual & reproductive health in women

Much less is known about how diabetes affects women’s sexual health. What we do know are the main sexual problems that women, with or without diabetes, deal with:

  • Vaginal dryness
  • A decrease in sexual desire
  • Pain during sex
  • Trouble having an orgasm
  • More vaginal thrush (yeast infection).

 

It’s still unclear whether diabetes has any impact at all. But if you’re having a hard time coming to terms with living with diabetes, you’re more likely to experience sexual problems.

 

In most cases, keeping blood glucose levels within your target range will reduce your risk of thrush and urinary tract infection.

During periods or menopause, your blood glucose levels may change. We recommend speaking with your GP or diabetes educator to adjust your treatment.

  • Talk to your doctor or healthcare professional about your sexual problems in the same way you would any other medical problem.
  • If you have a partner, talk through the problems you’re both experiencing.
  • Learn about the condition and what treatments are available to improve your sense of wellbeing.

 

Mental Health: People with diabetes have higher risk of developing mental health related problems such as depression, anxiety, or diabetes distress.

Read our special section about wellbeing and mental health and learn about our mental health and wellbeing support programmes.

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